Table 1.
SNPs and corresponding genes statistically significant when tested for ASE by Sequenom Assay.
| Gene | SNP_ID | fdr.p.values | Difference | SR ratio | Mode of ASE |
|---|---|---|---|---|---|
| DLK1 | rs1802710 | 3.62E-23 | 88.6 | 0.89 | Imprinting |
| PEG3 | rs1860565 | 2.74E-22 | 98.1 | 1.00 | Imprinting |
| IGF2 | rs680 | 2.32E-16 | 94.6 | 1.04 | Imprinting |
| PEG10 | rs13073 | 4.19E-08 | 98.4 | 0.84 | Imprinting |
| PHLDA2 | rs13390 | 4.19E-08 | 98.1 | 1.13 | Imprinting |
| DISC1 | rs821616 | 0.022009568 | 15.3 | 0.91 | Random ASE† |
| RASGRF1 | rs11855231 | 0.022009568 | 75.7 | 0.95 | Random mono† |
| C9orf93 | rs1539172 | 0.039790941 | 30.0 | 0.78 | Preferential† |
| TF | rs8649 | 0.04122505 | 56.9 | 0.78 | Random ASE† |
| ACSS2 | rs4911163 | 0.04122505 | 21.9 | 0.86 | Preferential |
| KIAA0523 | rs3744725 | 0.04122505 | 36.5 | 0.96 | Random ASE† |
The p-value is adjusted for multiple testing (false discovery rate bound). The average difference of expression between the two alleles in the cDNA of heterozygous individuals is greatest for imprinted genes. SR ratio is the ratio of genotyping success rate of cDNA on gDNA. Mode of ASE summarises the pattern of ASE based on the quantitative allelic expression data. †False positive pattern probably due to a low expression level (see text for details).