Table 3.
Age-adjusted and multivariable-adjusted association of electrocardiographic abnormalities with Coronary Artery Calcium and Common Carotid Intima-Media Thickness
| Age-Adjusted | Multivariable-Adjusted | ||||||
|---|---|---|---|---|---|---|---|
| CAC > 0 | N | Odds Ratio | Confidence Interval |
P- value |
Odds Ratio | Confidence Interval |
p- value |
| MEN | |||||||
| Isolated Minor NSTTA | 2647 | 1.18 | 0.93–1.50 | 0.18 | 1.04 | 0.81–1.33 | 0.78 |
| Any Minor ECG abnormality | 2647 | 1.21 | 1.01–1.44 | 0.04 | 1.10 | 0.91–1.32 | 0.33 |
| Any Major ECG abnormality | 3171 | 1.12 | 0.92–1.45 | 0.23 | 1.03 | 0.81–1.31 | 0.79 |
| WOMEN | |||||||
| Isolated Minor NSTTA | 3207 | 1.09 | 0.89–1.33 | 0.42 | 1.01 | 0.82–1.24 | 0.92 |
| Any Minor ECG abnormality | 3207 | 1.16 | 0.98–1.37 | 0.08 | 1.04 | 0.87–1.23 | 0.67 |
| Any Major ECG abnormality | 3539 | 1.07 | 0.83–1.38 | 0.58 | 0.94 | 0.73–1.22 | 0.64 |
| Log CAC |
Parameter estimate |
Confidence Interval |
p- value |
Parameter Estimate |
Confidence Interval |
p- value |
|
| MEN | |||||||
| Isolated Minor NSTTA | 1564 | −0.10 | −0.33–0.13 | 0.39 | −0.15 | −0.38–0.08 | 0.20 |
| Any Minor ECG abnormality | 1564 | 0.12 | −0.06–0.29 | 0.19 | 0.05 | −0.12–0.23 | 0.55 |
| Any Major ECG abnormality | 1940 | 0.17 | −0.03–0.36 | 0.10 | 0.08 | −0.12–0.27 | 0.44 |
| WOMEN | |||||||
| Isolated Minor NSTTA | 1235 | −0.01 | −0.23–0.21 | 0.94 | −0.07 | −0.29–0.16 | 0.55 |
| Any Minor ECG abnormality | 1235 | 0.06 | −0.13–0.25 | 0.53 | −0.01 | −0.20–0.18 | 0.89 |
| Any Major ECG abnormality | 1411 | 0.18 | −0.08–0.44 | 1.8 | 0.12 | −0.14–0.38 | 0.38 |
| CC-IMT(mm) |
Parameter Estimate |
Confidence Interval |
p- value |
Parameter estimate |
Confidence Interval |
p- value |
|
| MEN | |||||||
| Isolated Minor NSTTA | 2647 | 0.011 | −0.008–0.03 | 0.26 | −0.007 | −0.02–0.01 | 0.44 |
| Any Minor ECG abnormality | 2647 | 0.028 | 0.014–0.042 | 0.0001 | 0.015 | 0.001–0.029 | 0.03 |
| Any Major ECG abnormality | 3171 | 0.006 | −0.1–0.02 | 0.49 | −0.008 | −0.25–0.009 | 0.36 |
| WOMEN | |||||||
| Isolated Minor NSSTTA | 3207 | 0.006 | −0.009–0.02 | 0.45 | −0.004 | −0.018–0.01 | 0.60 |
| Any Minor ECG abnormality | 3207 | 0.008 | −0.004–0.019 | 0.21 | −0.003 | −0.014–0.009 | 0.063 |
| Any Major ECG abnormality | 3539 | 0.02 | 0.001–0.39 | 0.03 | 0.008 | −0.01–0.03 | 0.40 |
All regression models were adjusted for age, sex, and race initially; further adjustment for demographic and clinical covariates (age, smoking status, systolic blood pressure (SBP), blood pressure (BP) med, total cholesterol (TC), high-density lipoprotein (HDL), cholesterol med, diabetes (DM), body mass index (BMI)) was performed. ECG = electrocardiographic, CAC = coronary artery calcium, CC-IMT = common carotid intima-media thickness NSSTTA = non-specific ST segment and T wave abnormalities