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. Author manuscript; available in PMC: 2010 May 17.
Published in final edited form as: Pediatr Int. 2009 Feb;51(1):25–32. doi: 10.1111/j.1442-200X.2008.02648.x

Table 2.

PK/PD parameters from the simultaneous fits

Phlebotomy a (days) b-a (days) Emax (×108/day/kg) Emax/C50 (×108/day/kg)/(mU/mL) r†
1 0.740 5.63 255 44.3 0.913
2 1.69 1.53 725 126 0.947
3 0.552 6.42 149 25.9 0.983
4 1.10 4.70 152 26.4 0.982
5 0.135 4.82 188 32.7 0.952
6 1.04 2.91 531 92.3 0.984
7 1.21 6.03 210 36.4 0.968
8 1.71 3.60 266 46.2 0.965
9 0.680 6.36 154 26.8 0.955
10 0.040 6.81 104 18.1 0.904
Mean 0.889 4.88 273 47.5 0.955
% CV 64 35 73 73 3
†

Correlation coefficient for the fitted PK/PD model; C50 for the simultaneous estimations = 576 mU/mL.

PD, pharmacodynamic; PK, pharmacokinetic.