Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Mar 26;285(21):16066–16075. doi: 10.1074/jbc.M109.061416

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 3. — CXCL12 stimulates mobilization of intracellular calcium. A, CXCL12 in calcium-free buffer stimulated a dose-dependent increase in intracellular calcium. Treatment with the extracellular calcium chelator EGTA (3 mm) decreased persistent calcium mobilization in cells stimulated with 100 ng/ml CXCL12. B, CXCL12-stimulated calcium release is blocked by the cell-permeant chelator BAPTA-AM. Chemokine-induced calcium mobilization was completely blocked to control (no stim) levels by pretreatment with 10 μm BAPTA-AM. Pretreatment with 3 μm BAPTA-AM partially abrogated calcium mobilization. Values are relative Fluo-4 fluorescence units minus background signal from a representative of three separate experiments.