Skip to main content
. 2010 Mar 30;285(21):16125–16134. doi: 10.1074/jbc.M110.104356

FIGURE 2.

FIGURE 2.

Hsp90 is important to the function of all three dimer pairs but plays a minor role in ERβ homodimerization. a, co-treatment with the Hsp90 inhibitor 17-DMAG for 2 h, which did not induce ER degradation (inset), reduced E2-dependent dimerization of ERα/α homodimers, although ERβ/β homodimers and ERα/β heterodimers were minimally affected. b, co-treatment with 17-DMAG overnight, which induced ER degradation (inset), reduced E2-dependent dimerization of ERα/α homodimers and ERα/β heterodimers, although ERβ/β homodimers were minimally affected. Error bars represent mean ± S.D. *, statistically significant decrease in dimerization compared with E2 alone. Inset, lane 1, DMSO; lane 2, 10 nm E2; lane 3, 212 nm 17-DMAG; lane 4, 10 nm E2 + 212 nm 17-DMAG.