FIGURE 1.

Domain structure of Rb and interactions with E2F-DP. A, Rb consists of a structured N-terminal domain (RbN) and central pocket domain. Its C-terminal domain (RbC) is disordered except for a short sequence that adopts a structure upon E2F binding. Two other unstructured sequences, the interdomain linker (RbIDL) and pocket linker (RbPL), are indicated. Structured regions are colored, and the conserved consensus Cdk phosphorylation sites are marked. B, Rb makes two distinct contacts with E2F. The pocket domain binds the E2F transactivation domain (E2F^TD), and RbC binds the E2F-DP marked box domains.