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Effect of subcutaneous administration of R-PIA on zymosan-induced visceral hyperalgesia (A) and result of statistical analysis (B). R-PIA does not attenuated VMR to CRD at dose of 10 mg and 30 mg. At 100 mg, R-PIA decreases VMR to CRD without development of motor weakness (*p<0.05).
R-PIA, R(-)-N6-(2-phenylisopropyl)-adenosine; VMR, visceromotor response; CRD, colorectal distension.
