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Effect of subcutaneous administration of CGS-21680 on zymosan-induced visceral hyperalgesia (A) and result of statistical analysis (B). CGS-21680 attenuates VMR to CRD at doses of 30 mg and 100 mg (p<0.05) but not at 10 mg. At high dose, hindlimb weakness is produced (*p<0.05).
VMR, visceromotor response; CRD, colorectal distension.
