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Effect of intrathecal administration of NECA on zymosan-induced visceral hyperalgesia (A) and result of statistical analysis (B). NECA attenuates VMR to CRD at dose of 0.3 µg and 1.0 µg (p<0.05) but not at 0.1 µg. Both 0.3 µg, 1.0 µg of NECA produces motor weakness (*p<0.05).
NECA, 5-N-ethylcarboxyamidoadenosine; VMR, visceromotor response; CRD, colorectal distension.
