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Effect of intrathecal administration of R-PIA on zymosan-induced visceral hyperalgesia (A) and result of statistical analysis (B). R-PIA at doses of 0.1 µg does not induce decrease in VMR to CRD. However, 0.3 µg and 1.0 µg of intrathecal R-PIA produces decrease in VMR to CRD without development of motor weakness (*p<0.05).
R-PIA, R(-)-N6-(2-phenylisopropyl)-adenosine; VMR, visceromotor response; CRD, colorectal distension.
