Table 1. Summary results for six SNPs selected for genotyping in stage 2.

			RAFc					P valueg
Markera allele	Chrb position	Stage	Controls	Cases	Per allele ORd (95% CI)	Het. ORe (95% CI)	Hom. ORf (95% CI)	Stage	Combined
rs4657482	1	UK1	0.32	0.39	1.39 (1.21–1.59)	1.29 (1.07–1.57)	2.03 (1.52–2.70)	1.6 × 10−6
G/A	164098273	UK2	0.33	0.36	1.14 (0.99–1.31)	1.15 (0.94–1.41)	1.29 (0.95–1.75)	0.07	2.0 × 10−6
rs4699052	4	UK1	0.60	0.67	1.38 (1.20–1.57)	1.27 (0.95–1.70)	1.82 (1.36–2.45)	3.0 × 10−6
T/C	104357239	UK2	0.61	0.66	1.21 (1.05–1.39)	1.10 (0.81–1.48)	1.40 (1.04–1.90)	0.008	2.1 × 10−7
rs4624820	5	UK1	0.55	0.64	1.47 (1.29–1.67)	1.41 (1.08–1.84)	2.12 (1.62–2.78)	4.6 × 10−9
G/A	141661972	UK2	0.54	0.62	1.37 (1.19–1.58)	1.27 (0.96–1.67)	1.83 (1.38–2.44)	6.7 × 10−6	3.3 × 10−13
rs210138	6	UK1	0.20	0.27	1.50 (1.30–1.74)	1.40 (1.16–1.70)	2.57 (1.77–3.73)	4.5 × 10−8
A/G	33650516	UK2	0.20	0.27	1.50 (1.28–1.75)	1.58 (1.29–1.94)	1.99 (1.31–3.01)	6.6 × 10−7	1.1 × 10−13
rs995030	12	UK1	0.80	0.90	2.29 (1.88–2.78)	3.85 (1.37–10.82)	8.41 (3.02–23.37)	1.9 × 10−18
A/G	87414802	UK2	0.80	0.91	2.55 (2.05–3.19)	2.63 (0.94–7.31)	6.70 (2.43–18.49)	1.2 × 10−19	1.0 × 10−31
rs1508595	12	UK1	0.83	0.92	2.55 (2.05–3.18)	5.31 (1.26–22.31)	12.9 (3.11–53.58)	1.9 × 10−19
A/G	87510147	UK2	0.83	0.93	2.69 (2.10–3.44)	2.22 (0.67–7.31)	6.05 (1.87–19.55)	4.9 × 10−18	2.6 × 10−30

^adbSNP rs number and nonrisk/risk associated alleles.

^bChromosome and build 36 position.

^cFrequency of the risk allele.

^dOR, odds ratio.

^eOR in heterozygotes, relative to common homozygotes.

^fOR in homozygotes, relative to common homozygotes.

^gCochran-Armitage test for trend.