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. Author manuscript; available in PMC: 2010 May 17.
Published in final edited form as: Glia. 2007 Apr 1;55(5):453–462. doi: 10.1002/glia.20467

Fig. 6.

Fig. 6

Systemic TNFα increases IL-1β, NF-κB, and MCP-1 expression in TNFR1/R2+/+ (WT) mice. TNFR1/R2+/+ (WT) and TNFR1/R2−/− (KO) mice were injected with saline or TNFα (0.25 mg/kg) intraperitoneally. Brain mRNA expression of IL-1β and NF-κB-p65 and MCP-1 protein content were measured using real-time PCR and ELISA 1 h following saline or TNFα treatment. (A) Brain mRNA expression of IL-1β and NF-κB-p65 is increased by systemic TNFα in wild type mice, but not in TNFα receptor double KO mice. (B) Systemic TNFα administration increases brain MCP-1 protein in WT mice, but not in TNFR-KO mice. The results are the means ± SEM of two independent experiments performed with six mice for each treatment. *P < 0.05, **P < 0.01, compared to the corresponding saline control mice.