Table 1.
Published genome-wide association studies for schizophrenia: all schizophrenia GWA studies published to date are shown. The number of variants investigated, the best associated SNP(s) found and the gene(s) containing that SNP(s), the corresponding p-value(s) and the number of cases and controls in the discovery and the replication/meta-analysis sample are all given.
| Study | # SNPs analyzed | Supported variant | Supported gene | p-value discovery | # Samples discovery | p-value combined | # Samples replication/meta analysis |
|---|---|---|---|---|---|---|---|
| Mah et al. (2006) | ∼25,000 | rs752016 | plexin A2 (PLXNA2) | 0.006 | 320 cases, 325 controls | 0.035 | 200 cases, 230 controls (EA) |
| Lencz et al. (2007) | ∼500,000 | rs4129148 | colony stimulating factor, receptor 2 alpha (CSF2RA) | 3.7 × 10−7 | 178 cases, 144 controls | ||
| Sullivan et al. (2008) | ∼500,000 | rs4846033 | 4.4 × 10−6 | 738 cases, 733 controls | |||
| O'Donovan et al. (2008) | ∼500,000 | rs1344706 | zink finger protein 804A (ZNF804A) | 1.8 × 10−6 | 479 cases, 2937 controls | 1.6 × 10−7 | 7308 cases, 12834 controls |
| Shifman et al. (2008) | ∼500,000 | rs7341475 | reelin (RELN) | 2.9 × 10−5 (in females) | 745 cases, 2644 controls | 8.8 × 10−7 in females) | 2274 cases, 4401 controls |
| Kirov et al. (2009b) | ∼550,000 | rs11064768 | coiled coiled domain containing 60 (CCDC60) | 1.2 × 10−6 | 574 trios | ||
| Need et al. (2009) | ∼550,000 | rs2135551 | ADAMTS like 3 (ADAMTSL3) | 1.3 × 10−6 | 871 cases, 863 controls | 1460 cases, 12995 controls | |
| Shi et al. (2009) | ∼600,000 | rs13025591 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 (AGAP1) | 4.6 × 10−7 (in EA) | 2681 cases, 2653 controls (EA); 1286 cases, 973 controls (AA) | ||
| rs1851196 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4) | 2.1 × 10−6 (in AA) | |||||
| rs9272219 rs9272535 rs13194053 | major histocompatibility complex (MHC) cluster of histone protein genes | 6.9 × 10−8 8.9 × 10−8 9.5 × 10−9 | 8008 cases 19077 controls (EA) | ||||
| International Schizophrenia Consortium (2009) | ∼1,000,000 | rs5761163 | myosin XVIIIB (MYO18B) | 3.4 × 10−7 | 3322 cases, 3587 controls | 8008 cases, 19077 controls | |
| rs13194053 | major histocompatibility complex (MHC) | 9.5 × 10−9 | |||||
| Stefansson et al. (2009) | ∼300,000 | 5 variants | major histocompatibility complex (MHC) | 2663 cases, 13498 controls | 1.1 × 10−9 1.4 × 10−12 | 12945 cases, 34591 controls | |
| rs12807809 | neurogranin (NRGN) | 2.4 × 10−9 | |||||
| rs9960767 | transcription factor 4 (TCF4) | 4.1 × 10−9 |
Genome-wide significant findings are highlighted in bold.
EA, European Ancestry Individuals; AA, African American Individuals.