Table 2.

Main Types of EGFR Exon 19 Deletions and Corresponding Amino Acid Sequences

Deletion size	AA mutation	AA sequence	COSMIC (n = 1531)
	No mutation	IKELREATSPKANKEIL
Del-9	L747_E749del	IK…EATSPKANKEIL	6.4%
	K745_L747del	I…REATSPKANKEIL	0.2%
Del-12	E746_E749del	IK… .ATSPKANKEIL	0.2%
Del-15	E746_A750del*	IK… . .TSPKANKEIL	68.1%
	L747_T751del	IKE… . .SPKANKEIL	6.4%
	K745_E749del	I… . .ATSPKANKEIL	0.9%
	A750_K754del	IKELRE… . .ANKEIL	0.12%
Del-18	E746_T751del	IK… …SPKANKEIL	0.7%
	L747_S752del	IKE… …PKANKEIL	2.4%
	E746_S752>X†	IK… …XPKANKEIL	3.8%
	L747_P753del	IKE… … .KANKEIL	0.4%
	L747_P753>Q	IKE… …QKANKEIL	1.1%
	L747_P753>S	IKE… …SKANKEIL	6.7%
Del-24	E746_P753del	IK… … .KANKEIL	0.4%
	L747_K754del	IKE… … .ANKEIL	0.12%
	A750_K757del	IKELRE… … .EIL	0.12%
	T751_E758del	IKELREA… … .IL	0.06%
	S752_I759del	IKELREAT… … .L	0.7%

The proportions among the 1531 Exon 19 deletion cases collected in COSMIC are indicated.

^*15-bp deletion mutant used to generate the antibody.

^†Complex deletion encoding novel amino acid (X), which varies between samples.