Table 7.
Staining Intensity with the Exon 19 Deletion Mutant-Specific Antibody versus Sequence Results for the 15-bp and 18-bp EGFR Exon 19 Deletion Mutants
| Deletion size | AA mutation | AA sequence | CDS mutation | n | IHC 0 | IHC 1+ | IHC 2+ | IHC 3+ |
|---|---|---|---|---|---|---|---|---|
| Del-15 | E746_A750del* | IK… . . TSPKANKEIL | Del 2235-2249 | 14 | 0 | 1 | 7 | 6 |
| E746_A750del* | IK… . . TSPKANKEIL | Del 2236-2250 | 4 | 0 | 1 | 3 | 0 | |
| L747_T751del | IKE… . . SPKANKEIL | Del 2240-2254 | 1 | 0 | 0 | 1 | 0 | |
| NA | 1 | 0 | 0 | 0 | 1 | |||
| Del-18 | L747_S752del | IKE… … PKANKEIL | Del 2239-2256 | 1 | 0 | 0 | 0 | 1 |
| E746_S752>V | IK… … VPKANKEIL | Del 2237-2255>T (complex) | 4 | 1 | 2 | 1 | 0 | |
| L747_P753>Q | IKE… … QKANKEIL | Del 2239-2258>CA (complex) | 1 | 0 | 0 | 0 | 1 | |
| L747_P753>S | IKE… … SKANKEIL | Del 2240-2257 | 10 | 5 | 4 | 1 | 0 | |
| NA | 1 | 1 | 0 | 0 | 0 |
*
Deletion mutant used for monoclonal antibody production.