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Summary of IHC and Molecular Assays for the EGFR L858R Mutation
| Mutation + | Mutation − | Total | |
|---|---|---|---|
| IHC results versus mutation analysis by PCR-RFLP assay only | |||
| IHC+ | 17 | 5 | 22 |
| IHC− | 1 | 171 | 172 |
| Total | 18 | 176 | 194 |
| IHC results versus combined results of PCR-RFLP and Sequenom assays | |||
| IHC+ | 20 | 2 | 22 |
| IHC− | 1 | 171 | 172 |
| Total | 21 | 173 | 194 |
Based on the combined results, the sensitivity is 95.2% (20/21) and the specificity is 98.8% (171/173).
