Table 1.
Characteristics of Samples Used to Compare Performance of 10K2.0, 250K Nsp, and SNP6.0 Arrays
| FISH Panel |
Array |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CLL# | %CLL CD19+/ CD5+ | MYB 6q22-q23 | ATM 11q22.3 | MDM2 12q14.3-q15 | 13q 13q14.3/ 13q34 | IgH 14q32.3 | p53 17p13.1 | 10K2.0 | 250K | 6.0 | Comment |
| CLL28 | 0.67 | 2.4% | 79.8% | 73.0% | 0.0% | 0.5% | 0.0% | OK | OK | OK | FISH missed 13q14 deletion |
| CLL29 | 0.44 | 1.5% | 0.0% | 0.0% | 2.9% | 0.0% | 2.0% | OK | OK | OK | |
| CLL30 | 0.41 | 2.0% | 1.0% | 0.0% | 62.7% | 1.5% | 0.0% | Fail | OK | ND | 10K resolution too low |
| CLL31 | 0.66 | 1.0% | 86.0% | 0.0% | 2.0% | 0.0% | 0.0% | OK | OK | OK | |
| CLL32 | 0.26 | 1.5% | 1.0% | 23.1% | 0.0% | 1.5% | 1.0% | OK | OK | Fail/OK | SNP6.0 fails at low percent tumor using GTC |
| CLL33 | 0.85 | 0.5% | 0.5% | 0.0% | 95.3% | 0.0% | 0.0% | OK | OK | OK | |
The percentage of cells showing significant abnormalities by FISH are underlined.