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. 2010 Mar;12(2):197–203. doi: 10.2353/jmoldx.2010.090046

Figure 1.

Figure 1

MLPA analysis of three CLL patients. A: Height ratio plot from a patient with heterozygous 13q14.1 and ATM deletions, normalized to that of a normal control. Copy number changes are seen as small red squares that lie outside the threshold detection (green line), which was set at 0.8–1.2. Small green and blue squares represent normal copy number of genes detected by a probe mix specific for CLL chromosomal sequences (green squares) and internal control probes (blue squares) targeting other chromosomes. MLPA probe amplification products below 130 nt represent DNA quantity control fragments. B: A CLL patient with homozygous 13q14.1 deletion. C: A peak profile method of viewing MLPA analysis. Each peak represents a specific probe amplification product. We show a CLL patient (blue) with heterozygous 13q14.3 deletion and trisomy 12 compared with a normal control group (red).