Table 4.

Sensitivity of MLPA for Detecting a 13q14.3 Deletion in Decreasing Number of CLL Cells

Proportion of CLL/normal DNA (%)	FISH	MLPA*
1. 97.0	98	+
2. 48.5	49	+
3. 36.4	23	+
4. 24.3	9	+†
5. 12.1	18	−
6. 0.0	3	−

^*A positive signal indicates that more than two probes for this deletion had a RCN outside the normal range of 0.85–1.2. The patient was heterozygous for this deletion.

^†The abnormality was only detected in one of three assays at this dilution. All other results were consistent between three assays.