Table 1.

Genes involved in major mitochondria-associated neurodegenerative diseases

Abbreviations: AD, Alzheimer's disease; DNM1L, dynamin-1 like protein (DRP1); HD, Huntington disease; HTRA2, HtrA2 serine peptidase (OMI); HTT Huntingtin (Htt); IM, inner membrane; IMS, Inner membrane space; LRRK2, leucine-rich repeat kinase 2; OM, outer membrane; OPA1, optic atrophy protein 1, autosomal dominant; PARK2, Parkinson disease autosomal recessive, juvenile 2 (parkin); PARK7, Parkinson disease autosomal recessive, early onset 7 (DJ-1); PARL, presenilin-associated rhomboid-like protein; PD, Parkinson's disease; PINK1, PTEN-induced putative kinase 1; PPARGC1A, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1); PPID, peptidylprolyl isomerase D (cyclophilin D; CYPD); PREP, prolyl endopeptidase (PreP); SNCA, α-synuclein; TRAP1, TNF-receptor-associated protein 1 (Hsp75).