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. 2010 Mar 3;115(2):547–556. doi: 10.1093/toxsci/kfq071

FIG. 5.

FIG. 5.

Effect of ATP and purinergic receptor antagonists on NiSO4-induced cell proliferation. BrdU immunoreactivity in the turbinates of animals treated with (A) 0 mg/kg NiSO4 (0 day), (B–D) saline vehicle, (F–H) purinergic receptor antagonists, or (J–L) ATP following instillation of NiSO4 (2.5 mg/kg) at 3, 5, or 7 days postinstillation. Dashed lines delineate basal lamina. Scale bar = 10 μm. (E and I) Quantification of BrdU+ cells (E) or OE thickness (I) in turbinates. *p < 0.01 versus vehicle control (two-way ANOVA). #p < 0.05 and ##p < 0.01 versus saline/NiSO4-treated animals (two-way ANOVA).