FIG. 4.

Pdp1 regulates components of xenobiotic metabolism. (A–C) Time of day and Pdp1-dependent Cyp6g1, Cyp6a2, and α-Esterase-7 mRNA expression levels in control and Pdp1 RNAi flies. Data represent mean relative expression (+ SEM) for three independent experiments. ANOVA and Tukey's multiple comparison post-test were used to determine statistical significance from control ZT 4 samples where *p < 0.05, **p < 0.01, and ***p < 0.001. (D) Flies with disrupted Pdp1 expression have significantly lower general esterase activity for α-naphthyl acetate. Significant difference from control ZT 4 was determined by an ANOVA and Bonferonni post-test, p < 0.05. See also Supplementary figure 2.