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. 2010 Mar 24;115(2):569–576. doi: 10.1093/toxsci/kfq084

FIG. 5.

FIG. 5.

Nitrite-mediated antagonism of cyanide inhibition of CcOX. (A) Time course of NaNO2-mediated inhibition of CcOX. Cellular CcOX activity was determined at specific times of incubation with NaNO2 (100μM). (B) Antagonism of cyanide inhibition of CcOX by NaNO2. Cells were pretreated with NaNO2 (100μM) for the indicated time, followed by incubation with KCN (20μM) for 10 min and then CcOX activity determined. Data represent mean ± SEM of six determinations. *Significantly different from untreated control group; #significantly different from KCN-treated group. p < 0.05.