Table 4. Immunophenotypical analysis of the main lymphocyte subsets involved in immunosenescence.

		Mean (%)± S.E.MA			P valueB
Lymphocyte subsets		C	S	Y	C vs S	S vs Y	C vs Y
Naïve T lymphocytes (CD45RA+CCR7+)	T helper	15.3±2.5	22.5±1.3	33.1±2.0	0.008	<0.0001	<0.0001
	T cytotoxic	12.9±1.4	15.7±1.2	33.9±2.3		<0.0001	<0.0001
Central Memory T lymphocytes (CD45RA-CCR7+)	T helper	34.8±3.5	21.5±1.9	13.7±1.1	<0.001	0.009	<0.0001
	T cytotoxic	11.4±1.2	9.8±1.5	5.0±0.6		0.03	<0.0001
Effector Memory T lymphocytes (CD45RA-CCR7-)	T helper	42.2±2.8	40.8±1.7	37.8±2.2
	T cytotoxic	47.3±3.5	42.5±2.0	33.4±2.3		0.007	0.002
Terminal Effector T lymphocytes (CD45RA+CCR7-)	T helper	7.6±1.1	15.2±1.6	15.4±0.7	0.03		<0.0001
	T cytotoxic	28.5±3.9	32.0±2.6	27.7±2.2
Effector T lymphocytes (CD28−)	T helper	10.7±2.0	9.5±1.6	3.5±1.2		<0.001	0.001
	T cytotoxic	48.2±5.4	49.8±3.7	28.6±4.4		0.002	0.02
Activated T lymphocytes (CD25+)	T helper	26.6±2.6	23.8±1.5	29.2±1.8		0.03
	T cytotoxic	13.3±2.9	6.6±0.7	5.5±0.4	0.003		0.001

^AResults are expressed as mean percentage of T helper and T cytotoxic lymphocytes ± S.E.M (standard error of the mean).

^BP values <0.05 are reported.