Table I.
Number of genes significantly modulated in 6 microarray analyses comparing the pre-receptive or receptive stages between natural and stimulated cycles.
| Study | Number of samples | Natural cycle (number of samples) | Stimulated cycle (number of samples) | Paired analysis | Fold change | Number of genes | |
|---|---|---|---|---|---|---|---|
| Up | Down | ||||||
| Mirkin et al. (2004) | 13 | LH+8 (n=5) | hCG+9 Atg (n=5) | Partially | ≥ 1.19 | 6 | 6 |
| LH +8 (n=5) | hCG+9 Ag (n=3) | ≥ 1.2 | 5 | 1 | |||
| Horcajadas et al. (2005) | 19 | LH +7 (n=14) | hCG +7 (n=5) | No | ≥ 3 | 281 | 277 |
| Simon et al. (2005) | 28 | LH +7 (n=14) | hCG +7 Atg standard dose (n=4) | No | ≥ 2 | 22 | 69 |
| LH +7 (n=14) | hCG +7 Atg high dose (n=5) | 88 | 24 | ||||
| LH +7 (n=14) | hCG +7 Ag (n=5) | 22 | 100 | ||||
| Horcajadas et al. (2008) | 49 | LH+1 (n=5) | hCG+1 (n=5) | No | - | 0 | 0 |
| LH+2 (n=5) | hCG+2 (n=5) | 0 | 0 | ||||
| LH+3 (n=5) | hCG+3 (n=5) | 0 | 0 | ||||
| LH+5 (n=5) | hCG+5 (n=4) | 0 | 0 | ||||
| LH+7 (n=5) | hCG+7 (n=5) | 69 | 73 | ||||
| LH+9 (n=5) | hCG+9 (n=5) | 0 | 0 | ||||
| Liu et al. (2008) | 13 | LH+7 (n=5) | hCG+7 high serum E2 levels (n=4) | No | ≥ 2 | 244 | 159 |
| LH+7 (n=5) | hCG+7 low serum E2 levels (n=4) | 5 | 2 | ||||
| Current study | 84 | LH+2 (n=21) | hCG+2 (n=21) | Yes | ≥ 2 | 321 | 4 |
| LH+7 (n=21) | hCG+5 (n=21) | 657 | 0 | ||||
This table compares our gene lists significantly modulated between LH+2 and hCG+2, and between LH+7 and hCG+5 with five other studies using the same approach. Atg, antagonist; Ag, agonist.