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. 2010 May 27;365(1546):1679–1696. doi: 10.1098/rstb.2010.0025

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Figure 2. — Location of occludin and claudin in the seminiferous epithelium. Occludin- and claudin-based tight junctions are components of the BTB, which is located apical to preleptotene spermatocytes and basal to pachytene spermatocytes in the seminiferous epithelium. Both occludin and claudin interact with scaffolding proteins (ZO-1, -2, and -3) and occludin interacts with the signalling molecule FAK. These interactions with scaffolding proteins connect occludin and claudin to the actin cytoskeleton and allow localization of cell signalling molecules to tight junctions. Through these various interactions, tight junctions can influence cell cycle pathways.