Table 2.
Biomarker values over the course of the study.
| Plasma total NNAL concentration (fmol/ml) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Sampling mo. | N | Median | Mean | Std Dev | 95% LCL | 95% UCL | Minimum | Maximum |
| 0 | 66 | 31.8 | 37.8 | 26.7 | 31.2 | 44.4 | 8.0 | 173.4 |
| 2 | 64 | 32.9 | 38.1 | 24.9 | 31.9 | 44.3 | 4.5 | 155.8 |
| 4 | 62 | 32.4 | 37.0 | 22.9 | 31.2 | 42.8 | 2.0 | 154.6 |
| 6 | 59 | 26.8 | 36.8 | 29.5 | 29.1 | 44.5 | 3.2 | 162.5 |
| 8 | 59 | 28.8 | 35.1 | 25.3 | 28.5 | 41.7 | 5.8 | 159.7 |
| 10 | 57 | 33.9 | 39.7 | 22.7 | 33.7 | 45.7 | 0.0 | 111.7 |
| 12 | 57 | 36.3 | 41.3 | 19.0 | 36.3 | 46.4 | 12.8 | 99.3 |
| Plasma total cotinine concentration (ng/ml) | ||||||||
| Sampling mo. | N | Median | Mean | Std Dev | 95% LCL | 95% UCL | Minimum | Maximum |
| 0 | 66 | 211.22 | 230.02 | 100.36 | 205.35 | 254.69 | 38.90 | 549.82 |
| 2 | 64 | 226.94 | 239.41 | 113.86 | 210.97 | 267.85 | 39.43 | 680.88 |
| 4 | 62 | 223.35 | 235.93 | 110.46 | 207.88 | 263.98 | 44.17 | 669.85 |
| 6 | 59 | 222.35 | 230.56 | 112.06 | 201.35 | 259.76 | 32.61 | 581.20 |
| 8 | 59 | 238.26 | 233.10 | 100.85 | 206.82 | 259.38 | 42.50 | 508.89 |
| 10 | 58 | 215.24 | 236.73 | 108.69 | 208.15 | 265.31 | 8.00 | 493.51 |
| 12 | 57 | 234.93 | 240.79 | 100.82 | 214.03 | 267.54 | 42.17 | 482.43 |
| Plasma PheT concentration (fmol/ml) | ||||||||
| Sampling mo. | N | Median | Mean | Std Dev | 95% LCL | 95% UCL | Minimum | Maximum |
| 0 | 66 | 78.8 | 109.5 | 114.8 | 81.3 | 137.8 | 15.4 | 830.9 |
| 2 | 64 | 75.9 | 109.8 | 130.5 | 77.2 | 142.4 | 19.3 | 956.8 |
| 4 | 62 | 74.9 | 131.5 | 199.7 | 80.8 | 182.2 | 17.6 | 1095.2 |
| 6 | 59 | 74.9 | 99.1 | 117.2 | 68.5 | 129.6 | 13.4 | 885.0 |
| 8 | 59 | 70.1 | 96.6 | 131.3 | 62.4 | 130.8 | 12.9 | 971.0 |
| 10 | 57 | 64.2 | 88.6 | 63.2 | 71.9 | 105.4 | 26.3 | 344.1 |
| 12 | 57 | 77.4 | 170.3 | 304.5 | 89.5 | 251.1 | 26.1 | 2066.5 |
| Urine total NNAL concentration (pmol/mg creatinine) | ||||||||
| Sampling mo. | N | Median | Mean | Std Dev | 95% LCL | 95% UCL | Minimum | Maximum |
| 0 | 66 | 1.17 | 1.39 | 0.92 | 1.17 | 1.62 | 0.39 | 5.51 |
| 2 | 62 | 1.11 | 1.43 | 0.96 | 1.18 | 1.67 | 0.44 | 5.34 |
| 4 | 62 | 1.17 | 1.49 | 1.01 | 1.23 | 1.75 | 0.30 | 5.80 |
| 6 | 57 | 1.14 | 1.38 | 1.04 | 1.10 | 1.65 | 0.24 | 5.27 |
| 8 | 57 | 1.16 | 1.44 | 1.18 | 1.13 | 1.76 | 0.18 | 6.74 |
| 10 | 57 | 1.23 | 1.62 | 1.70 | 1.17 | 2.07 | 0.24 | 12.06 |
| 12 | 55 | 1.08 | 1.57 | 1.85 | 1.07 | 2.07 | 0.37 | 13.05 |
| Urine total cotinine concentration (ng/mg creatinine) | ||||||||
| Sampling mo. | N | Median | Mean | Std Dev | 95% LCL | 95% UCL | Minimum | Maximum |
| 0 | 67 | 3422 | 4099 | 2445 | 3503 | 4696 | 753 | 17625 |
| 2 | 64 | 3526 | 4265 | 2957 | 3526 | 5004 | 659 | 17823 |
| 4 | 63 | 3453 | 4266 | 2819 | 3556 | 4976 | 650 | 13114 |
| 6 | 61 | 3504 | 4287 | 3037 | 3510 | 5065 | 583 | 17181 |
| 8 | 60 | 3776 | 3826 | 2280 | 3237 | 4415 | 611 | 13562 |
| 10 | 59 | 3504 | 3883 | 2473 | 3239 | 4528 | 22 | 14159 |
| 12 | 59 | 2948 | 3537 | 2426 | 2905 | 4170 | 422 | 12458 |
| Urine total nicotine per concentration (ng/mg creatinine) | ||||||||
| Sampling mo. | N | Median | Mean | Std Dev | 95% LCL | 95% UCL | Minimum | Maximum |
| 0 | 67 | 1889 | 2387 | 2407 | 1800 | 2974 | 310 | 17460 |
| 2 | 64 | 1777 | 2345 | 2783 | 1650 | 3040 | 320 | 21448 |
| 4 | 63 | 1905 | 2849 | 2899 | 2119 | 3579 | 257 | 14917 |
| 6 | 61 | 1706 | 2459 | 2524 | 1813 | 3106 | 118 | 14105 |
| 8 | 60 | 2108 | 2639 | 2800 | 1916 | 3363 | 186 | 19392 |
| 10 | 59 | 1557 | 2374 | 3092 | 1568 | 3180 | 15 | 20844 |
| 12 | 59 | 1432 | 2120 | 2140 | 1562 | 2678 | 429 | 13500 |
Abbreviations: Std Dev = standard deviation; LCL = lower confidence limit; UCL = upper confidence limit