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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Resuscitation. 2009 Oct 4;80(12):1431–1436. doi: 10.1016/j.resuscitation.2009.09.005

Table 1. Laboratory Parameters.

Resuscitation 60 min
 Resuscitation 90 min
Baseline Shock 0 μM 10 μM 50 μM 0 μM 10 μM 50 μM
Hct, % 49 ± 2 28 ± 1† 23 ± 1† 23 ± 1† 22 ± 1 † 22 ± 2† 21 ± 2† 21 ± 2 †
Hb, g/dl 14.7 ± 0.6 9.3 ± 0.4 † 7.4 ± 0.3 † 7.1 ± 0.4 † 7.0 ± 0.4 † 6.8 ± 0.4† 6.8 ± 0.3† 6.7 ± 0.4 †
MetHb, % -- -- -- 2.7 ± 1.2 5.8 ± 1.8 -- 1.9 ± 1.1 3.1 ± 1.3
Plasma Nitrite, nM 442 ± 96 742 ± 128 804 ± 132 842 ± 124
PaO2, mmHg 56.2 ± 6.2 87.4 ± 8.0† 78.6 ± 6.7† 68.8 ± 6.4† 79.5 ± 7.4† 76.3 ± 5.6† 69.0 ± 6.1† 68.3 ± 5.6†
PaCO2, mmHg 54.5 ± 5.2 38.2 ± 6.3† 43.5 ± 3.5† 47.1 ± 6.8 42.3 ± 3.8† 41.5 ± 4.2† 48.9 ± 4.9 46.4 ± 6.2
Arterial pH 7.342 ± 0.017 7.207 ± 0.026† 7.320 ± 0.027 7.351 ± 0.026 7.372 ± 0.027 7.322 ± 0.021 7.361 ± 0.018 7.385 ± 0.035
BE, mmol/l 3.3 ± 1.7 −4.8 ± 2.0† −1.3 ± 1.4† 1.6 ± 2.2 −0.9 ± 1.7† −2.4 ± 1.8† 2.2 ± 1.9 1.6 ± 2.3
Viscosity, cP
Blood 4.2 ± 0.4 2.7 ± 0.3† 2.6 ± 0.3† 2.6 ± 0.3†
Plasma 1.2 ± 0.1 1.5 ± 0.2† 1.5 ± 0.2† 1.4 ± 0.2†
COP, mmHg 17.8 ± 1.6 17.1 ± 1.1 16.6 ± 0.9 16.7 ± 0.8

0 μM, resuscitation followed by 100 μl saline without nitrite; 10 μM, resuscitation followed by 100 μl of 10μM nitrite in saline; 50 μM, resuscitation followed by 100 μl of 50μM nitrite in saline. Values are means ± SD. Baseline and shock included all the animals in the study. Hct, systemic hematocrit; Hb, hemoglobin content of blood; MeHb, fraction of methemoglobin; MAP, mean arterial blood pressure; PaO2, arterial partial O2 pressure; PaCO2, arterial partial pressure of CO2; BE, base excess. Shear rate of 160 s−1 at 37°C; COP, colloid osmotic pressure at 27°C. Values are means ± SD.

†

P<0.05 compared to Baseline.