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. Author manuscript; available in PMC: 2011 May 7.

Published in final edited form as: J Org Chem. 2010 May 7;75(9):3069–3084. doi: 10.1021/jo1003136

Hoechst cell permeable dye and Annexin-V binding were used to observe nuclear morphology after exposure to compound 45 or 46. Cells with brightly stained, condensed nuclei are considered to be apoptotic (a). Apoptosis was confirmed by Annexin-V binding after 48hr exposure to either 45 or 46 at 0.5 μM concentration (b).

Hoechst cell permeable dye and Annexin-V binding were used to observe nuclear morphology after exposure to compound 45 or 46. Cells with brightly stained, condensed nuclei are considered to be apoptotic (a). Apoptosis was confirmed by Annexin-V binding after 48hr exposure to either 45 or 46 at 0.5 μM concentration (b).