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. Author manuscript; available in PMC: 2011 May 7.
Published in final edited form as: J Org Chem. 2010 May 7;75(9):3069–3084. doi: 10.1021/jo1003136

Table 1.

Human Cancer Cell Line and Murine P-388 Lymphocytic Inhibitory Activities. P388 Murine Lymphoceutic Leukemia and Human Cancer Cell Results [μg/mL] (ED 50)

Compound leukemia pancreas breast CNS lung-NSC colon prostate leukemia neuroblastoma
P388 BxPC-3 MCF-7 SF-268 NCI-H460 KM20L2 DU-145 Jurkat Shsy5y
2 0.039 0.028 0.032 0.017 0.048 0.062 0.016 0.163 0.163
3 0.44 0.29 0.22
4 0.001 0.026 0.019 0.021 0.032 0.021 0.011
7 0.029 0.046 0.034 0.059 0.043 0.051 0.040
51 0.0016 0.0019 0.00031 0.00055 0.0001 0.00037 0.00021
52 0.061 0.25 0.041 0.17 0.029 0.13 0.13
45 0.19 0.65 0.09 0.26 1.615 1.615
46 0.11 0.29 0.11 0.37 0.183 0.183
HHS Vulnerability Disclosure