Table 2.

Manifestations of cGVHD

Organ	Signs	Symptoms
Skin, Nails, Hair	Sclerosis, lichen sclerosus-like, lichen planus-like features Sweat impairment Ichthyosis Keratosis pilaris Hypo-, hyper -, de-pigmentation Erythema, poikiloderma Maculopapular rash Nail dystrophy Pterygium unguis Alopecia Scaling, papulosquamous lesions of scalp Hair depigementation	Pruritus Dryness Longitudinal ridging, splitting of nail Nail loss Thinning of hair Premature graying
Vulvovaginal	Lichen planus-like features Vaginal scarring or stenosis Erosions, fissures, ulcers	Dyspareunia Vaginal dryness
Muscles, Fascia, Joints	Fasciitis Sclerosis Myositis or polymyositis Edema	Joint stiffness or contractures Muscle cramps or pain Arthralgia or arthritis Weakness
Eyes	Cicatricial conjunctivitis Keratoconjunctivitis sicca Punctate keratopathy Blepharitis	Dry, gritty, or painful eyes Photophobia
Mouth	Erythema Lichen-type features Hyperkeratotic plaques Xerostomia Mucocele Mucosal Atrophy Pseudomembrane formation Ulcers Gingivitis, mucositis	Dry mouth Pain Difficulty swallowing Oral sensitivity Change in taste Increased dental caries
GI Tract	Esophageal web or strictures Exocrine pancreatic insufficiency Vomiting Diarrhea	Anorexia Nausea Weight loss, failure to thrive Abdominal cramping
Liver	Hyperbilirubinemia Tranaminitis	Jaundice
Lung	Bronchiolitis obliterans BOOP	Dyspnea on exertion
Hematopoeitic/Immune	Anemia, Thrombocytopenia, Eosinophilia Hypo- or hyper-gammaglobulinemia Autoantibodies (AIHA, ITP)
Other	Effusions Peripheral neuropathy Nephrotic syndrome Myasthenia gravis Cardiac conduction abnormality Cardiomyopathy Coronary artery fibrotic changes	Varied