Table 2.
Volumetric Characteristics of the 24 ROIs, Whole Brain and Calcarine Area in the LLD Subjects (N = 71) and the Comparison Subjects (N = 32)
| Region of interest | Comparison group mean (SD) | LLD subjects mean (SD) | P-Value FDR adjusted |
|---|---|---|---|
| Whole braina | 515438.44 (61121.12) | 518236.03 (63063.89) | 0.834 |
| Calcarine areaa | 13170.53 (2480.30) | 14289.28 (2317.03) | 0.044 |
| Frontal superior area | 1.43 (0.32) | 1.32 (0.24) | 0.082 |
| Frontal superior orbital area | 0.59 (0.11) | 0.54 (0.09) | 0.029 |
| Frontal middle area | 2.11 (0.43) | 1.95 (0.34) | 0.066 |
| Frontal orbital areab | 2.08 (0.38) | 1.89 (0.27) | 0.012 |
| Frontal inferior areac | 1.59 (0.29) | 1.47 (0.24) | 0.044 |
| Frontal superior medial area | 1.06 (0.28) | 0.92 (0.18) | 0.011 |
| Rectus | 0.50 (0.11) | 0.45 (0.08) | 0.029 |
| Insula | 1.22 (0.26) | 1.06 (0.18) | 0.006 |
| Cingulum aread | 1.97 (0.34) | 1.85 (0.27) | 0.066 |
| Cingulum posterior | 0.21 (0.06) | 0.20 (0.03) | 0.417 |
| Hippocampus | 0.83 (0.13) | 0.75 (0.11) | 0.007 |
| Parahippocampal area | 0.84 (0.16) | 0.78 (0.11) | 0.044 |
| Amygdala | 0.26 (0.04) | 0.22 (0.04) | 0.003 |
| Parietal superior area | 0.86 (0.20) | 0.83 (0.15) | 0.477 |
| Parietal inferior area | 0.97 (0.22) | 0.89 (0.15) | 0.044 |
| Precuneus | 1.62 (0.29) | 1.59 (0.21) | 0.557 |
| Caudate | 0.93 (0.19) | 0.89 (0.18) | 0.457 |
| Putamen | 1.24 (0.23) | 1.11 (0.18) | 0.007 |
| Pallidum | 0.44 (0.09) | 0.40 (0.07) | 0.047 |
| Thalamus | 1.00 (0.20) | 0.88 (0.15) | 0.006 |
| Temporal superior area | 1.47 (0.31) | 1.29 (0.21) | 0.006 |
| Temporal polee | 1.44 (0.34) | 1.30 (0.21) | 0.026 |
| Temporal middle area | 2.56 (0.45) | 2.31 (0.33) | 0.011 |
| Temporal inferior area | 1.93 (0.37) | 1.78 (0.25) | 0.029 |
a
For whole brain and calcarine area measured in mm3.
b
Frontal lateral orbital+frontal inferior orbital+frontal middle orbital.
c
Frontal inferior operculum+frontal inferior_Tri.
d
Cingulum anterior+cingulum middle.
e
Temporal pole superior+temporal pole middle.