TABLE 2.
Role of crosstalk in platelet sensitization.
| Condition | Integral shear stress (dyne·s/cm2) |
Platelet activation rate (ΔPAS/min) (×10−4 min−1) |
p-Values |
|---|---|---|---|
| (a) Platelet count | |||
| 20000/µL | 2800 | 45.1 ± 17.2 | – |
| 150000/µL | 2800 | 36.8 ± 8.9 | >0.5 |
| (b) Effect of quiescent platelets | |||
| Quiescent platelets only | 40 | 3.5 ± 5.3 | <0.1 |
| Sensitized platelets only | 2400 | 50.8 ± 30.1 | – |
| Sensitized + quiescent platelets | 2400 | 51.8 ± 15.0 | >0.8 |
| (c) Apyrase (1 U/mL) | |||
| Untreated | 2800 | 114.6 ± 6.4 | – |
| Apyrase-treated | 2800 | 76.9 ± 15.2 | <0.05 |
Platelet activation rates are means ± SEM for the post-exposure, low-shear phase (see “Results” section). (a) Effect of platelet count. (b) Effect of sensitized platelets on quiescent platelets. (c) Effect of apyrase addition.