Table 2. Characteristics of 9585 patients enrolled on CCG trials between 1988-2002.
| Features at initial diagnosis | Total number of patients | Number of patients in CCR (% of overall group) | # of relapsed patients (% in relapsed group) | 5-year EFS (SE) | |
|---|---|---|---|---|---|
| Gender | Male | 5374 | 4195 (55.0) | 1179 (60.1)* | 74.0 (0.6)@ |
| Female | 4211 | 3429 (45.0) | 782 (39.9) | 77.6 (0.7) | |
| Age | <1 year | 250 | 151 (2.0) | 99 (5.1)* | 40.1 (3.2)@ |
| 1-9.99 years | 6940 | 5626 (73.8) | 1314 (67.0) | 79.2 (0.5) | |
| ≥ 10 years | 2395 | 1847 (24.2) | 548 (27.9) | 68.5 (0.1) | |
| Race | White | 6830 | 5514 (72.3) | 1316 (67.1)* | 77.1 (0.5)@ |
| Black | 507 | 373 (4.9) | 134 (6.8) | 67.6 (2.4) | |
| Hispanic | 1636 | 1262 (16.6) | 374 (19.1) | 72.5 (1.2) | |
| Other | 612 | 475 (6.2) | 137 (7.0) | 73.6 (2.0) | |
| WBC | <50K | 7344 | 5974 (78.4) | 1370 (69.9)* | 78.6 (0.5) |
| 50-100K | 1009 | 776 (10.2) | 233 (11.9) | 70.4 (1.6) | |
| >100K | 1227 | 870 (11.4) | 357 (18.2) | 61.9 (1.6) | |
| Unknown | 5 | 4 | 1 | ||
| CNS Status | CNS 1 | 8359 | 6743 (90.3) | 1616 (84.3)* | 77.1 (0.5) |
| CNS 2 | 706 | 514 (6.9) | 192 (10.0) | 66.3 (1.9) | |
| CNS 3 | 317 | 208 (2.8) | 109 (5.7) | 58.1 (3.0) | |
| Unknown | 203 | 159 | 44 | ||
| Testicular disease | Normal | 5173 | 4040 (98.2) | 1133 (97.8) | 74.2 (0.7) |
| Enlarged | 101 | 76 (1.8) | 25 (2.2) | 65.0 (5.1) | |
| Unknown/NA | 4311 | 3508 | 803 | ||
| Immunophenotype | |||||
| B-lineage | 5754 | 4470(85.6) | 1284 (86.5) | 75.2 (0.6) | |
| T-lineage | 953 | 752 (14.4) | 201 (13.5) | 73.0 (1.6) | |
| Other/unknown | 2878 | 2402 | 476 | ||
*
p-value < 0.001 (Significant difference in clinical characteristic between relapsed vs. did not relapse)
@
p-value < 0.001 (Significant differences in EFS between categories for the clinical characteristic)