Figure 4.
Reduced [glucose]e opens K+ channels in rat CA3 pyramidal neurons. A, I–V relationship of the outward current generated with reduced [glucose]e. The ramp voltage command (−50 mV to −150 mV at 100 mV/s) was applied before (1) and during (2) reduced [glucose]e application. The reversal potential (E rev) of the outward current was −92.75 ± 1.67 mV (n = 4). The I–V relationship showed inward rectification and the average E rev was similar to the equilibrium potential for K+: −92.89 mV. B, BaCl2 (1 mm) reversed (left trace and right panel; n = 5) or prevented (pretreatment, right panel; n = 4) completely the outward current caused with reduced glucose.