Fig. 3.

Effect of parameter modifications on internalized virus concentration and spread volume. The values for the total concentration of internalized virus outside the initial distribution volume and the spread volume are shown, normalized to the values in the baseline simulation. Concentrations are at 4 hours after the beginning of the simulation and spread volumes are maximum values. A, effect of changes in the binding kinetics and diffusion coefficient on virus distribution. A decrease in the binding affinity or an increase in the diffusion coefficient increases the spread volume significantly. B, effect of changes in the degradation and internalization rate constant on viral distribution. An increase in the degradation rate or decrease in the internalization rate result in a significant decrease in the amount of virus but has no effect on the spread volume.