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SA-4-1BBL conjugate vaccine has robust efficacy in eradicating established 3LL tumors. C57BL/6 mice were challenged with 3LL tumor cells and vaccinated s.c. on day 6 post-tumor challenge with survivin (10 μg) conjugated or nonconjugated with SA-4-1BBL (25 μg) or an equimolar quantity of SA (10 μg). ** P < 0.001 for conjugated SA-4-1BBL-survivin vs. all other groups.
