Skip to main content
. Author manuscript; available in PMC: 2011 May 15.
Published in final edited form as: Cancer Res. 2010 Apr 20;70(10):3945–3954. doi: 10.1158/0008-5472.CAN-09-4480

Figure 6.

Figure 6

SA-4-1BBL conjugates serve as an effective therapeutic vaccine in TC-1 lung metastasis model. C57BL/6 mice (n = 3 per group) were challenged with live TC-1 cells by i.v. tail injection and vaccinated i.v. on day 6 post-tumor challenge with E7 (10 μg) conjugated with SA-4-1BBL (25 μg) or an equimolar quantity of SA (10 μg). A, mice were euthanized 21 d after tumor challenge and lungs were weighed, and (B) photographed after injection with Indian ink to assess tumor nodules. ** P < 0.001 and * P < 0.05. Data are representative of a minimum of three independent experiments for each panel.