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. Author manuscript; available in PMC: 2011 May 20.
Published in final edited form as: J Phys Chem B. 2010 May 20;114(19):6642–6652. doi: 10.1021/jp1001258

Figure 2.

Figure 2

Three catalytic strategies proposed for phosphodiester cleavage by the hairpin ribozyme. (A) Mechanism with G8− as the general base accepting a proton from the A−1(2′-OH) nucleophile. (B) Mechanism in which A38H+ acts as the general acid protonating the leaving G1(O5′) alcoholate. (C) Mechanism in which A38 acts as a proton shuttle accepting a proton from the A−1(2′-OH) nucleophile and transferring it to the leaving group G1(O5′).

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