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. Author manuscript; available in PMC: 2010 Jun 12.

Published in final edited form as: Chem Rev. 2010 May 12;110(5):2756–2782. doi: 10.1021/cr900266s

In vivo noninvasive PA images of rat brain hemodynamic changes includingtotal hemoglobin concentration (HbT) and oxygen saturation of hemoglobin (SO₂). (A) and (B) Structural brain images under normoxia at 584 and 600 nm laser light, respectively. (C) and (D) Images of SO₂ and HbT in the cortical venous area under normoxia. (E) The differential <SO₂> (the averaged SO₂ level) image between normoxia and hyperoxia (hyperoxia - normoxia). (F) The differential <SO₂>image between normoxia and hypoxia (hypoxia - normoxia). (G) The fractional change in HbT (<ΔHbT>/<HbT>) between hyperoxia and normoxia. (H) The fractional change in HbT between hypoxia and normoxia. (I) Open-skull anatomical photograph taken after the PA imaging experiments. (Reprinted with permission from ref 15. Copyright 2006 Society of Photo-Optical Instrumentation Engineers.)

In vivo noninvasive PA images of rat brain hemodynamic changes includingtotal hemoglobin concentration (HbT) and oxygen saturation of hemoglobin (SO₂). (A) and (B) Structural brain images under normoxia at 584 and 600 nm laser light, respectively. (C) and (D) Images of SO₂ and HbT in the cortical venous area under normoxia. (E) The differential <SO₂> (the averaged SO₂ level) image between normoxia and hyperoxia (hyperoxia - normoxia). (F) The differential <SO₂>image between normoxia and hypoxia (hypoxia - normoxia). (G) The fractional change in HbT (<ΔHbT>/<HbT>) between hyperoxia and normoxia. (H) The fractional change in HbT between hypoxia and normoxia. (I) Open-skull anatomical photograph taken after the PA imaging experiments. (Reprinted with permission from ref 15. Copyright 2006 Society of Photo-Optical Instrumentation Engineers.)