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. Author manuscript; available in PMC: 2010 Jun 12.
Published in final edited form as: Chem Rev. 2010 May 12;110(5):2756–2782. doi: 10.1021/cr900266s

Figure 45.

Figure 45

In vivo noninvasive molecular PA images of U87MG tumors before and after the injection of SWNTs-RGD and plain-SWNTs. The structural ultrasound image is shown in gray scale and the PA image is shown in green scale. (A) Time-course composite of US and PA images before and after SWNT-RGD and plain-SWNT. Subtraction image: PA image at 4 h post-injection – control PA image. White arrows in the left column indicate the PA signals in the mouse injected with plain-SWNT. (B) Averaged image intensities within the tumor region as a function of time after injection of SWNTs-RGD (n = 4, red solid line) and plain-SWNTs (n = 4, blue solid line). (Reprinted with permission from ref 19. Copyright 2008 Nature.)