Figure 4.

Simulations with the five-site allosteric model. (A) The rate of fusion plotted versus intraterminal [Ca²⁺]. Open circles represent rates of fusion derived from Thoreson et al. (1) and our estimate of spontaneous release. Open square depicts a weighted highpoint adapted from Kreft et al. (16). Shown are the best simulations to the data in the absence (solid curve) and presence (dashed curve) of the weighted highpoint (dashed curve). (B) Latency to postsynaptic current onset plotted against the intraterminal [Ca²⁺]. The best simulations using five-site allosteric model in the absence (solid curve) and presence (dashed curve) of a weighted high point. (C) Parallel coordinates plot of posterior distribution of normalized parameters in the absence (left) or presence of a weighted highpoint (right). Darker lines indicate better fits. Green and red lines are the mean and best fit, respectively.