Table 3.
Model | β/α (μM) | Time to leave fully-bound state (μs) | Off-rate of first Ca2+ to unbind (s−1) | Time for last Ca2+ to leave (ms) |
---|---|---|---|---|
Five-site A | 1.15 | 1213 | 145 | 6.8 |
Five-site A∗ | 3.17 | 143 | 146 | 6.8 |
Five-site A∗† | 2.61 | 165 | 141 | 7.1 |
Three-site A | 4.69 | 150 | 73 | 13.7 |
Three-site A∗ | 4.5 | 325 | 148 | 6.6 |
Three-site C‡ | 2.32 | 319 | 54 | 18.5 |
Two-site C‡ | 1.98 | 273 | 14 | 71.4 |
Bipolar cell (3) | 214 | 285 | 128 | 0.5 |
Hair cell (6) | 77 | 508 | 55 | 0.465 |
Calyx five-site C (5) | 105 | 103 | 37 | 0.105 |
Calyx five-site A (7) | 40 | 138 | 250 | 0.25 |
Calyx dual sensor, fast (8) | 38 | 164 | 23 | 0.172 |
Calyx dual sensor, slow (8) | 44 | 160 | 130 | 7.69 |
Chromaffin cell three-site C (31) | ≈10 | 700–2000 | ≈130 | 7.69 |
A, allosteric model; C, denotes conventional model.
With weighted high point.
With spontaneous point at 50 nM Ca2+.
No weighted high point, no spontaneous point.