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Possible configurations of dsDNA in the α-hemolysin vestibule and docking of dsDNA in the trans part of the stem. Note that, in the backward case, the double-stranded part can penetrate 1.4 nm into the stem. The Lysines 147 corresponding to the vestibule/stem constriction are highlighted in red. The threonines 125 are in orange. (For the sake of clarity, the 3′ single strand overhang is not represented here; however, were it to be represented, it should span the entire stem.)
