Fig. 2.

(A) Rescuing effects of Korea red ginseng against H. pylori-induced inflammation or cytotoxicity [46] Red ginseng could block several pathways to H. pylori-associated gastric damages including the connection between inflammation and carcinogenesis. They can block signal transduction pathway to inflammatory signals, attenuate apoptosis execution, and repress redox sensitive transcriptional activation. (B) Inhibitory activities and attenuated expression of 5-LOX with red ginseng in H. pylori-infected gastric epithelial cells [47]. Besides of COX-2 activation after H. pylori infection, H. pylori infection triggered 5-LOX activation, leading to increased production of 5(S)-HETE. Red ginseng showed efficient blockade to 5-LOX activation as equivalently efficient to 5-LOX inhibitors, geraniin.