Figure 1.

Structural representations of the E. coli ClC exchanger. Equilibrated structures of the ClC exchanger with the primary pore (A) and the secondary pore (B) are shown, and two structures are shown overlapped in C to compare the structural differences between A and B. Two chloride ions are represented as green spheres in A, and the pores predicted by the HOLE program are shown with a yellow transparent color in A and B. The structures in A and B are colored red and blue, respectively, in C. The D-, F-, and N-helices are shown by cartoon representation, and key residues are shown in stick representation. All of the snapshot figures in this work were created with PyMOL (http://www.pymol.org).