Table 3.
Experimental binding results and stage two ranking for four compstatin variants and the native compstatin
| Sequence | Approximate binding affinity rank | KD (M) | Model |
|---|---|---|---|
| Variant E1 | 11 | 0.19 × 10−06 | Two-state reaction |
| 0.23 × 10−06 | 1:1 binding | ||
| SQ059 | 14 | 0.74 × 10−06 | Two-state reaction |
| 0.45 × 10−06 | 1:1 binding | ||
| SQ027 | 1 | 0.76 × 10−06 | Two-state reaction |
| 0.51 × 10−06 | 1:1 binding | ||
| SQ086 | 10 | 0.99 × 10−06 | Two-state reaction |
| 0.50 × 10−06 | 1:1 binding | ||
| Native | 18 | 1.26 × 10−06 | Two-state reaction |
| 0.81 × 10−06 | 1:1 binding |