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Sxl negatively regulates both Notch expression and signaling. (A and B) Sxl overexpressed under the regulation of the dpp-Gal4 driver (A, marked by GFP, green) down-regulates N protein levels (B, gray). (C–F) Sxl overexpression (C and E, marked by GFP, green) down-regulates the expression of N signaling target genes Cut (D) and Dpn (F).
