Skip to main content
. 2010 Mar 15;107(15):7036–7041. doi: 10.1073/pnas.1000645107

Fig. 1.

Fig. 1.

Metabolic features of APP+-ob/ob mice. (A) Appearance of APP+ and APP+-ob/ob mice at 8 weeks. (B) Body weight changes in WT, APP+, ob/ob, and APP+-ob/ob mice (n = 12–14 per group). Blood glucose levels (C) and plasma insulin concentrations (D) at 8 weeks of age (n = 5–9). (E) Blood glucose levels during glucose tolerance test at 8 weeks (n = 5–14) and AUCs of blood glucose (Right) during GTT. (F and G) ITT in ob/ob and APP+-ob/ob mice (2.0 U/kg, n = 13–17, F), and WT and APP+ mice (0.5 U/kg, n = 5–6; G) at 8 weeks. (H) Immunoblot analysis of Ser473-phosphorylated Akt (pAkt) and total Akt in response to a bolus injection of insulin in skeletal muscle and liver. (I) Densitometric quantification of all immunoblot analysis from H (n = 3–7). (J) Daily food (Left) and water (Middle) intake and urine volume (Right) in ob/ob and APP+-ob/ob mice at 8 weeks (n = 7–9). (K) Basal activity (mean locomotion score) of ob/ob and APP+-ob/ob mice in open-field test (n = 6–9). ##P < 0.01, APP+-ob/ob versus APP+ mice; *P < 0.05 and **P < 0.01, APP+-ob/ob versus ob/ob mice. NS, not significant.