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Physical self-assembly of nanogels in aqueous media. (a) Aggregation of hydrophobically-modified polymer, cholesterol-pullulan, in the presence of insulin molecules results in nanogels containing entrapped protein. (b) Mixing of lauryl-modified dextran and β-cyclodextrin polymer results in formation of nanogels stabilized through the guest-host binding of the lauryl and β-cyclodextrin moieties.
